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KMID : 0360220090500030383
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 3 p.383 ~ p.389
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Pegylated Interferon Associated Retinopathy in Chronic Hepatitis Patients
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Kang Hee-Young
Lim Ji-Won
Shin Min-Chul
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Abstract
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Purpose: To investigate clinical features of pegylated interferon?associated retinopathy in chronic hepatitis patients.
Methods: The present study was a consecutive case series of 46 patients who were treated with pegylated interferon for chronic hepatitis C or B from October 2007 to September 2008 in our hospital. The patients had a regular ophthalmologic examination every 3 weeks for 6 months after treatment.
Results: Out of 46 patients, 10 patients (21.73%) developed retinal abnormality. Pegylated interferon?associated retinopathy occurred at 7.25±10.28 weeks after the treatment with cotton?wool spots and retinal hemorrhage. All cases except one mild nonproliferative diabetic retinopathy case presenting broad perimacular non?perfusion recovered without cessation of the treatment.
Conclusions: Pegylated interferon?associated retinopathy in chronic hepatitis patients was reversible and had a recovery without visual complication. However, a single case did present with irreversible visual impairment. Pegylated interferon?associated retinopathy is usually asymptomatic and clinicians should observe patients closely for 3 months after treatment.
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KEYWORD
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Chronic hepatitis, Pegyalated interferon, Retinopathy
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